Dr. T. Thuy Minh Nguyen
Assistant Professor of Biochemistry
Ph. (409) 880-7262
Fax (409) 880-8270
Our group is interested in the role of sterols in the development of Cancer cells. Recent investigations in our laboratory have shown that mutations induced by exposure to ultra-violet radiation (UV) caused an increase in the amount of sterol found in the cellular membranes of a variety of cell types. Since UV is a known cancer agent, our hypothesis is that some types of sterol molecules help the formation of cancerous cell membranes. We therefore study the effect of changing the amount of sterol on cellular membrane structure through various means including site-directed mutagenesis, protein labelling, development of inhibitors, kinetics studies and analysis of cell membrane composition with GC, HPLC, IR and NMR.
T. T. M. Nguyen*, V. R. Chintamsetti, S. Chennuru "The Stability of Lipid Rafts-Like Micro-Domains Is Dependent on the Available Amount of Cholesterol" Journal of Biophysical Chemistry, 2016, 7, 74-85.
T. T. M. Nguyen*, M. D. Baviskar, P. Bernazzani "Potential of Magnetotactic Bacteria for the Fabrication of Iron Nanoparticles" TMS 2017 146th Annual Meeting & Exhibition Supplemental Proceedings, 2017, 13-21.
M. Jao, F. Ahmed, G. Sudani, T. T. M. Nguyen*, M. C. Wang "Interaction between Strip Footings and Sheet pile Walls" Electronic Journal of Geotechnical Engineering, 2017, 22.06, 1655-1674. Available at ejge.com.
T. T. M. Nguyen*, S. K. Lageshetty, P. Bernazzani "Enhanced Physical Properties of Thin Film Nanocomposites" Characterization of Minerals, Metals, and Materials, 2017, 147-160. DOI 10.1007/978-3-319-51382-9_17.